"Changing the World One Smile at a Time."
Smile Train is a charity whose mission it is to provide free cleft surgery and to train doctors and medical professionals in cleft-related operations. The charity focuses solely on that goal, putting to use all available resources to reach it.
According to Wikipedia's article on Smile Train and the Smile Train site itself, approximately 1 in 700 children are born with cleft lip and palate. Though the number of children being born with cleft lip and palate is strikingly large, Smile Train claims that it is currently fixing more cleft lips and palates than the rate at which people are being born with it, thus hopefully nearing eradication of the problem.
A cleft lip and palate surgery (and treatment) costs around just $250. While that is a large sum for any one person to donate, Smile Train claims that a person can help by simply donating a small portion of that, paying for something as important as the medications. It accumulates all of the money, and then uses that to pay for the surgery and treatment.
Cleft lip and palate can be a severe hindrance to the lives of innocent children around the world, breeding social and personal issues. You can help with just a small donation to Smile Train.